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研討會內容
| 研討會名稱 | 第二十六屆校友專題演講-鄭新霖博士 |
|---|---|
| 開始日期 | 2017-04-19 11:00:00 |
| 結束日期 | 2017-04-19 12:00:00 |
| 活動說明 | 由臺北醫學大學醫學院醫學系神經內科學科於2017年4月19日(星期三)，特別邀請第26屆校友鄭新霖博士進行專題演講-Painful Diabetic Neuropathy: from Clinical Management to Bench Studies，以促進學術之合作交流。 演講摘要:The prevalence of type 2 diabetes has been increasing exponentially. Patients with diabetic neuropathy from type 2 diabetes report a significantly decreased quality of life caused by painful diabetic neuropathy (PDN). PDN causes a length-dependent burning, tingling, or “shock-like sensations” with increased sensitivity to both painful (hyperalgesia) and nonpainful stimuli (allodynia). These symptoms frequently persist despite the use of currently available treatments. The development of mechanism-specific treatments for PDN is in an urgent need. We use db/db mice as a model of PDN to study the molecular mechanisms underlying PDN. Accumulating evidence suggests that nerve growth factor (NGF)-mediated neuronal signaling is essential for the development of PDN. The NGF-p38 signaling in primary sensory neurons induces cytokine upregulation and neurogenic inflammatory reactions in peripheral nerves. Inhibition of NGF-p38 signaling significantly reduces cytokine-mediated inflammation and pain behaviors. Our results provide evidence that new treatments that target NGF-mediated neurogenic inflammation could be effective for treating PDN from type 2 diabetes. |
| 主要聯絡Mail | com@tmu.edu.tw |
| 參考連結 | |
| 附件檔案 | Poster_speech  |
