【主题】：全国性家庭资料之建立及其遗传流行病學之应用 (Nationwide genealogy reconstruction and its application in genetic epidemiology)
【内容】： Genetic epidemiology is a discipline to decipher gene-environmental interaction. The most important parameters used include heritability, sibling recurrence risk ratio and probability of sporadicity. Generally it is based on threshold liability model and requires a large population-based sample to do the analysis. In addition, it needs precise information for family structure and linked health information to identify patients and their family history correctly. We have started the work to do nationwide genealogy reconstruction using the National Health Insurance Research Database and have studied genetic epidemiology of rheumatic diseases. In this talk, I plan to share my experience on the method to do nationwide genealogy reconstruction and its application in genetic epidemiology.
