活动摘要
| 研讨会名称 | 【拇山生物医學研究讲座】112/5/4 演讲者：徐嘉琳副教授 (国立阳明交通大學微生物及免疫學研究所) |
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| 开始日期 | 2023-05-04 10:00:00 |
| 结束日期 | 2023-05-04 12:00:00 |
| 活动说明 | 【拇山生物医學研究讲座】 时间：112年5月4日（四） 上午10:00-12:00 地点：医學综合大楼後栋16楼 国際会议厅 演讲者：徐嘉琳副教授 （国立阳明交通大學微生物及免疫學研究所） 演讲题目：: IFN-stimulated metabolite transporter ENT3 facilitates viral genome release 演讲摘要： An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this talk, we are going to discuss the findings that the expression of equilibrative nucleoside transporter 3 （ENT3, encoded by solute carrier family 29 member 3, Slc29a3） is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene （ISG）. Suprisingly, we unveil that several viruses, including SARSCoV-2, require ENT3 to facilitate their entry into the cytoplasm.The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage. |
| 主要联絡Mail | lu99@tmu.edu.tw |
| 参考连结 | http://gims.tmu.edu.tw/main.php |
| 报名开始日期 | 2023-04-21 08:00:00 |
| 报名结束日期 | 2023-05-04 10:00:00 |
| 附件档案 | Biosketch_CHsu 2023 Apr Chinese  |
