Brief
| Seminar Title | 【拇山生物醫學研究講座】112/5/4 演講者：徐嘉琳副教授 (國立陽明交通大學微生物及免疫學研究所) |
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| Start Date | 2023-05-04 10:00:00 |
| End Date | 2023-05-04 12:00:00 |
| Introduction | 【拇山生物醫學研究講座】\r\n\r\n時間：112年5月4日（四） 上午10:00-12:00\r\n\r\n地點：醫學綜合大樓後棟16樓 國際會議廳\r\n\r\n演講者：徐嘉琳副教授 （國立陽明交通大學微生物及免疫學研究所）\r\n\r\n演講題目：: IFN-stimulated metabolite transporter ENT3 facilitates viral genome release \r\n\r\n演講摘要：\r\nAn increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this talk, we are going to discuss the findings that the expression of equilibrative nucleoside transporter 3 （ENT3, encoded by solute carrier family 29 member 3, Slc29a3） is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene\r\n（ISG）. Suprisingly, we unveil that several viruses, including SARSCoV-2, require ENT3 to facilitate their entry into the cytoplasm.The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.\r\n\r\n |
| Contact Email | lu99@tmu.edu.tw |
| Reference link | http://gims.tmu.edu.tw/main.php |
| Sign-up Date | 2023-04-21 08:00:00 |
| Sign-up Deadline | 2023-05-04 10:00:00 |
| Attached file | Biosketch_CHsu 2023 Apr Chinese  |
